Request for Concentration Data on Fragrance Ingredients

The RIFM Safety Assessment evaluation process focuses on individual fragrance materials, and the process more rapidly incorporates advances in in vitro and in silico methodologies. This focus allows RIFM to take advantage of advances in the science of safety evaluations and meet the increasingly stringent requirements from regulatory bodies and the increased expectations of fragrance users.

Exposure data are essential for completing a safety assessment for all endpoints. The Creme RIFM Aggregate Exposure Model is a probabilistic aggregate exposure model to calculate total systemic exposure, with distributions used to model various parameters. This model enables the measurement of real-life consumer exposure to a fragrance material.

RIFM has published four publications on the model in the peer-reviewed journal Regulatory Toxicology and Pharmacology (see http://fragrancematerialsafetyresource.elsevier.com).

This Excel spreadsheet lists the materials in this 50^th concentration survey. The Excel file contains two worksheets. The first worksheet contains the 158 fragrance materials included in this survey. 

Completion date is Jan. 2, 2026.

This portal link below will provide information on registration for transferring survey data and on completing the survey: http://rifmportal.cremeglobal.com/

Once registration is complete, the responder can copy data to the online Excel-style spreadsheet and submit responses for each fragrance ingredient. Each organization has a separate data submission site. A companion website will guide you through the new online data portal:  http://rifm.cremeglobal.com/manual/index.php/RIFM_Data_Portal

Additionally, RIFM Webinars held in February 2015, May 12, 2015, July 12, 2017, November 18, 2020, June 22, 2021, and February 7, 2023 explained in detail how to complete this survey and how the portal system works. Click on those links above to register for and view any webinars.

RIFM will follow due diligence to obtain exposure information. Materials for which usage concentration data are not provided will be added to the Not Supported List for 2025 and eliminated from the RIFM evaluation process in 2027 if the data are not received. At that time, RIFM will inform IFRA that, due to the lack of data, RIFM cannot complete a safety evaluation. IFRA will then review the material for possible risk management actions, including removal from the IFRA Transparency List and/or a ban due to insufficient data.